Tomball has been blessed with a robust network of streets and highways to service local, regional, and national markets. These roadways include:
- Interstate 45: Located less than 12 miles east of Tomball, this major transporation artery of Texas services markets from Dallas to Galveston.
- Beltway 8: Located less than 14 miles south of Tomball, Beltway 8 services the entire greater Houston area.
- State Highway 249: SH 249 runs straight through Tomball and services markets from Stagecoach to downtown Houston.
- State Highway 290: This east-west thoroughfare runs straight through Tomball and connects the community to I-45 to the east and Waller/State Highway 290 to the west.